Welcome to Fuchs Lab!
Lab Research Interests:
Ribosomes are found in all organisms and are essential for survival and growth. They are large complexes composed of RNA and protein molecules and translate the mRNA sequence into a protein sequence. Until recently it was through that all ribosomes within one organism, even within one single cell differ in posttranslational modifications and ribosome-associated proteins. Althrough many ribosome modifications have been identified, the impact these modifications have on protein biosynthesis is not clear.
Our lab uses cellular and molecular biology, biochemistry, virology as well as biophysical tolls to decrypt the ribosome code. We use mass spectrometry to identify ribosome modifications. To manipulate ribosome modifications and investigate how they alter translation of specific mRNAs we deplete known and putative modifying enzymes using siRNAs. Lastly, in addition to biochemical methods, our lab will use single-molecule techniques to study how these modifications affect the function of the ribosome.
- Ribosome composition in cells during stress and viral infections
- Ribosome subpopulations regulating translation
- Mechanism of translational regulation in mammalian cells
- Translational control in cancer cells
Ribosomes are found in all organisms and are essential for survival and growth. They are large complexes composed of RNA and protein molecules and translate the mRNA sequence into a protein sequence. Until recently it was through that all ribosomes within one organism, even within one single cell differ in posttranslational modifications and ribosome-associated proteins. Althrough many ribosome modifications have been identified, the impact these modifications have on protein biosynthesis is not clear.
Our lab uses cellular and molecular biology, biochemistry, virology as well as biophysical tolls to decrypt the ribosome code. We use mass spectrometry to identify ribosome modifications. To manipulate ribosome modifications and investigate how they alter translation of specific mRNAs we deplete known and putative modifying enzymes using siRNAs. Lastly, in addition to biochemical methods, our lab will use single-molecule techniques to study how these modifications affect the function of the ribosome.
Awards and Accomplishments
-> Check out our publication in J. Biol. Chem on "Molecular mechanism of poliovirus Sabin vaccine strain attenuation". Congratulations Clare and Gaby!
-> Congratulations to the graduate student, Clare Miller, for winning the Poster Award (3rd price) at 2018 Scientista Symposium in the Graduate Student Category.
-> Take a look of our new publication in Nucleic Acids Research titled "Positive-sense RNA viruses reveal the complexity and dynamics of the cellular and viral epitranscriptomes during infection".
-> A big shout out to our undergraduate researcher, Hyun Ah Yoon for being selected for the Early Assurance Program, Albany Medical College.
-> Congratulations to the graduate student, Clare Miller, for receiving the runner-up Award, Oral Presentation, Life Science Research Symposium, University at Albany, SUNY (2017).
-> Congratulations to to our undergraduate researcher, Diana Nikolyan for receiving the Undergraduate Research Endowed Fellowship for Biology by UAlbany.
-> Clare Miller was awarded with the Albert N. Husted Fellowship, Alumni Association Scholarship, University at Albany SUNY (2016). Congratulations, Clare!
-> Congratulations to to our undergraduate researcher, Caroline Apreku for securing the Full Summer Fellowship, DAAD RISE Germany Internship Position (2018).
->Congratulations Oluwatomi Alade for receiving the Outstanding Poster Presentation Award, Undergraduate Research Symposium Department of Biological Sciences, University at Albany.
-> Check out our publication in J. Biol. Chem on "Molecular mechanism of poliovirus Sabin vaccine strain attenuation". Congratulations Clare and Gaby!
-> Congratulations to the graduate student, Clare Miller, for winning the Poster Award (3rd price) at 2018 Scientista Symposium in the Graduate Student Category.
-> Take a look of our new publication in Nucleic Acids Research titled "Positive-sense RNA viruses reveal the complexity and dynamics of the cellular and viral epitranscriptomes during infection".
-> A big shout out to our undergraduate researcher, Hyun Ah Yoon for being selected for the Early Assurance Program, Albany Medical College.
-> Congratulations to the graduate student, Clare Miller, for receiving the runner-up Award, Oral Presentation, Life Science Research Symposium, University at Albany, SUNY (2017).
-> Congratulations to to our undergraduate researcher, Diana Nikolyan for receiving the Undergraduate Research Endowed Fellowship for Biology by UAlbany.
-> Clare Miller was awarded with the Albert N. Husted Fellowship, Alumni Association Scholarship, University at Albany SUNY (2016). Congratulations, Clare!
-> Congratulations to to our undergraduate researcher, Caroline Apreku for securing the Full Summer Fellowship, DAAD RISE Germany Internship Position (2018).
->Congratulations Oluwatomi Alade for receiving the Outstanding Poster Presentation Award, Undergraduate Research Symposium Department of Biological Sciences, University at Albany.
